Drug interactions
Dexamethasone-neomycin-polymyxin + Methadone
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone can induce CYP3A4 and lower methadone concentrations, possibly causing reduced analgesia or opioid withdrawal symptoms. The effect is more relevant with sustained systemic dexamethasone.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Methadone belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by dexamethasone increases methadone metabolism.
What to do
Monitor for withdrawal symptoms or loss of analgesia and titrate methadone as needed. Reassess the dose when dexamethasone is stopped, because levels may rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Methadone?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone can induce CYP3A4 and lower methadone concentrations, possibly causing reduced analgesia or opioid withdrawal symptoms. The effect is more relevant with sustained systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms or loss of analgesia and titrate methadone as needed. Reassess the dose when dexamethasone is stopped, because levels may rise.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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