Drug interactions
Dexamethasone-neomycin-polymyxin + Naproxen
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroid and NSAID therapy raises the risk of peptic ulcers and upper GI bleeding. The risk is mainly relevant when dexamethasone is systemically absorbed.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Naproxen belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal damage from corticosteroids and NSAID inhibition of protective prostaglandins.
What to do
Limit duration of both and prescribe a proton pump inhibitor for patients at GI risk. Monitor for melena or dyspepsia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Naproxen?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent corticosteroid and NSAID therapy raises the risk of peptic ulcers and upper GI bleeding. The risk is mainly relevant when dexamethasone is systemically absorbed.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit duration of both and prescribe a proton pump inhibitor for patients at GI risk. Monitor for melena or dyspepsia.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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