Drug interactions
Dexamethasone-neomycin-polymyxin + Nelfinavir
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can raise dexamethasone exposure, increasing the risk of Cushingoid effects and adrenal suppression with systemic use. Topical use has limited systemic absorption.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Nelfinavir belongs to Anti Virals.
Why it happens
Nelfinavir inhibits CYP3A4, reducing dexamethasone clearance.
What to do
Short topical courses need no change. With prolonged or systemic dexamethasone, use the lowest effective dose and monitor for steroid excess.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-neomycin-polymyxin and Nelfinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Nelfinavir?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and can raise dexamethasone exposure, increasing the risk of Cushingoid effects and adrenal suppression with systemic use. Topical use has limited systemic absorption.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Short topical courses need no change. With prolonged or systemic dexamethasone, use the lowest effective dose and monitor for steroid excess.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
