Drug interactions
Dexamethasone-neomycin-polymyxin + Nifedipine
Severity: Minor
Dexamethasone-neomycin-polymyxin and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a CYP3A4 inducer and may lower nifedipine exposure, reducing blood pressure or angina control. This applies mainly to systemic use; topical ophthalmic or otic use gives little systemic exposure.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Nifedipine belongs to Cardiovascular.
Why it happens
Dexamethasone induces CYP3A4, increasing nifedipine metabolism.
What to do
Where systemic dexamethasone exposure is meaningful, monitor blood pressure and anginal symptoms and increase the nifedipine dose if needed. No action is usually needed with topical use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Nifedipine
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Nifedipine?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a CYP3A4 inducer and may lower nifedipine exposure, reducing blood pressure or angina control. This applies mainly to systemic use; topical ophthalmic or otic use gives little systemic exposure.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where systemic dexamethasone exposure is meaningful, monitor blood pressure and anginal symptoms and increase the nifedipine dose if needed. No action is usually needed with topical use.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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