Drug interactions
Dexamethasone-neomycin-polymyxin + Nilotinib
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and lower nilotinib concentrations, potentially reducing anticancer efficacy. Nilotinib may in turn raise dexamethasone exposure modestly. With topical dexamethasone combinations the effect is likely negligible.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Nilotinib belongs to Oncology.
Why it happens
Dexamethasone induces CYP3A4, while nilotinib is a CYP3A4 and P-glycoprotein inhibitor.
What to do
If systemic dexamethasone is used, monitor treatment response and consider alternatives to strong CYP3A4 inducers. Monitor QTc with nilotinib per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Nilotinib?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may induce CYP3A4 and lower nilotinib concentrations, potentially reducing anticancer efficacy. Nilotinib may in turn raise dexamethasone exposure modestly. With topical dexamethasone combinations the effect is likely negligible.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If systemic dexamethasone is used, monitor treatment response and consider alternatives to strong CYP3A4 inducers. Monitor QTc with nilotinib per labeling.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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