Drug interactions
Dexamethasone-neomycin-polymyxin + Ofloxacin
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones and corticosteroids together increase the risk of tendinitis and tendon rupture, especially in older patients. The risk is mainly with systemic corticosteroid exposure.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive tendon toxicity from fluoroquinolone and corticosteroid effects on collagen and tenocytes.
What to do
Avoid the combination in older patients or those on prolonged systemic steroids when possible. Stop ofloxacin and rest the limb at the first sign of tendon pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Ofloxacin?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones and corticosteroids together increase the risk of tendinitis and tendon rupture, especially in older patients. The risk is mainly with systemic corticosteroid exposure.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients or those on prolonged systemic steroids when possible. Stop ofloxacin and rest the limb at the first sign of tendon pain.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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