Drug interactions
Dexamethasone-neomycin-polymyxin + Pimavanserin
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone, a CYP3A4 inducer, may reduce pimavanserin exposure and efficacy. Labeling advises dose increase with strong inducers.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Pimavanserin belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases pimavanserin metabolism.
What to do
Monitor for reduced antipsychotic effect and consider pimavanserin dose increase if systemic dexamethasone is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Pimavanserin?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone, a CYP3A4 inducer, may reduce pimavanserin exposure and efficacy. Labeling advises dose increase with strong inducers.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antipsychotic effect and consider pimavanserin dose increase if systemic dexamethasone is prolonged.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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