Drug interactions
Dexamethasone-neomycin-polymyxin + Primidone
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolised partly to phenobarbital, an enzyme inducer, and can lower dexamethasone concentrations. This could reduce steroid efficacy with systemic dosing.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Primidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by primidone and its metabolite phenobarbital accelerates dexamethasone metabolism.
What to do
With systemic dexamethasone, monitor clinical response and increase the dose if required. No action is needed for topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Primidone?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolised partly to phenobarbital, an enzyme inducer, and can lower dexamethasone concentrations. This could reduce steroid efficacy with systemic dosing.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, monitor clinical response and increase the dose if required. No action is needed for topical use.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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