Drug interactions
Dexamethasone-tobramycin + Diflunisal
Severity: Moderate
Dexamethasone-tobramycin and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID such as diflunisal raises the risk of gastric irritation, ulceration and gastrointestinal bleeding. The topical ophthalmic or otic use of dexamethasone-tobramycin carries lower exposure, but systemic risk rises with prolonged use or substantial absorption.
What this interaction means in plain words
Dexamethasone-tobramycin and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Diflunisal belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury: NSAIDs inhibit protective prostaglandins while corticosteroids impair mucosal healing.
What to do
Monitor for dyspepsia, melena or GI bleeding and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Use the shortest effective duration of both agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Diflunisal?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID such as diflunisal raises the risk of gastric irritation, ulceration and gastrointestinal bleeding. The topical ophthalmic or otic use of dexamethasone-tobramycin carries lower exposure, but systemic risk rises with prolonged use or substantial absorption.
How serious is the interaction between Dexamethasone-tobramycin and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dyspepsia, melena or GI bleeding and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Use the shortest effective duration of both agents.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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