Drug interactions
Dexamethasone-tobramycin + Duvelisib
Severity: Minor
Dexamethasone-tobramycin and Duvelisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may raise exposure to CYP3A4 substrates such as dexamethasone. Increased corticosteroid effects are possible with systemic use, while ophthalmic exposure is small.
What this interaction means in plain words
Dexamethasone-tobramycin and Duvelisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing dexamethasone clearance.
What to do
No adjustment is needed for ophthalmic use; with systemic dexamethasone monitor for corticosteroid adverse effects such as hyperglycemia and infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Duvelisib?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Duvelisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duvelisib inhibits CYP3A4 and may raise exposure to CYP3A4 substrates such as dexamethasone. Increased corticosteroid effects are possible with systemic use, while ophthalmic exposure is small.
How serious is the interaction between Dexamethasone-tobramycin and Duvelisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed for ophthalmic use; with systemic dexamethasone monitor for corticosteroid adverse effects such as hyperglycemia and infection.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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