Drug interactions
Dexamethasone-tobramycin + Etodolac
Severity: Moderate
Dexamethasone-tobramycin and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID such as etodolac increases the risk of gastric ulceration and gastrointestinal bleeding. Risk is greatest with systemic corticosteroid use or prolonged therapy.
What this interaction means in plain words
Dexamethasone-tobramycin and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Etodolac belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury from prostaglandin inhibition by the NSAID and impaired healing from corticosteroids.
What to do
Monitor for GI symptoms and bleeding, and consider a proton pump inhibitor in higher-risk patients. Limit the duration of combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Etodolac?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID such as etodolac increases the risk of gastric ulceration and gastrointestinal bleeding. Risk is greatest with systemic corticosteroid use or prolonged therapy.
How serious is the interaction between Dexamethasone-tobramycin and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI symptoms and bleeding, and consider a proton pump inhibitor in higher-risk patients. Limit the duration of combined therapy.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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