Drug interactions
Dexamethasone-tobramycin + Isavuconazonium
Severity: Moderate
Dexamethasone-tobramycin and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone, a CYP3A4 inducer, may lower isavuconazole concentrations and reduce antifungal efficacy. Isavuconazole may also raise dexamethasone exposure via CYP3A4 inhibition, and combined immunosuppression raises infection risk.
What this interaction means in plain words
Dexamethasone-tobramycin and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Isavuconazonium belongs to Anti Fungals.
Why it happens
Dexamethasone induces CYP3A4 reducing isavuconazole levels, while isavuconazole inhibits CYP3A4 and can increase dexamethasone levels.
What to do
Monitor clinical response to antifungal therapy, and consider therapeutic drug monitoring of isavuconazole. Watch for corticosteroid adverse effects and use the lowest effective dexamethasone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Isavuconazonium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Isavuconazonium?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone, a CYP3A4 inducer, may lower isavuconazole concentrations and reduce antifungal efficacy. Isavuconazole may also raise dexamethasone exposure via CYP3A4 inhibition, and combined immunosuppression raises infection risk.
How serious is the interaction between Dexamethasone-tobramycin and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to antifungal therapy, and consider therapeutic drug monitoring of isavuconazole. Watch for corticosteroid adverse effects and use the lowest effective dexamethasone dose.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
