Drug interactions
Dexamethasone-tobramycin + Pneumococcal vaccine 13-valent
Severity: Minor
Dexamethasone-tobramycin and Pneumococcal vaccine 13-valent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids may reduce the antibody response to inactivated vaccines. This is an efficacy concern rather than a safety one. Topical dexamethasone-tobramycin has negligible systemic effect.
What this interaction means in plain words
Dexamethasone-tobramycin and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
Corticosteroid immunosuppression may reduce vaccine immune response.
What to do
Vaccinate on schedule; with sustained high-dose systemic steroids consider revaccination or timing the vaccine when steroid dose is lower.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Dexamethasone-tobramycin with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic corticosteroids may reduce the antibody response to inactivated vaccines. This is an efficacy concern rather than a safety one. Topical dexamethasone-tobramycin has negligible systemic effect.
How serious is the interaction between Dexamethasone-tobramycin and Pneumococcal vaccine 13-valent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate on schedule; with sustained high-dose systemic steroids consider revaccination or timing the vaccine when steroid dose is lower.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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