Drug interactions
Dexamethasone-tobramycin + Quinidine
Severity: Minor
Dexamethasone-tobramycin and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and could raise levels of P-gp substrates, but the effect on dexamethasone and tobramycin is not clinically established. Tobramycin is eliminated mainly by glomerular filtration, and topical use gives minimal exposure.
What this interaction means in plain words
Dexamethasone-tobramycin and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits P-glycoprotein efflux, though the clinical relevance for these substrates is unclear.
What to do
No specific action is needed for topical use; with systemic tobramycin, monitor renal function and drug levels as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Quinidine?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine inhibits P-glycoprotein and could raise levels of P-gp substrates, but the effect on dexamethasone and tobramycin is not clinically established. Tobramycin is eliminated mainly by glomerular filtration, and topical use gives minimal exposure.
How serious is the interaction between Dexamethasone-tobramycin and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed for topical use; with systemic tobramycin, monitor renal function and drug levels as routine.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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