Drug interactions
Dexamethasone-tobramycin + Regorafenib
Severity: Moderate
Dexamethasone-tobramycin and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a CYP3A4 inducer and can lower regorafenib exposure while altering the balance of its active metabolites. This may reduce antitumor efficacy. The effect is mainly relevant with prolonged or high-dose steroid use.
What this interaction means in plain words
Dexamethasone-tobramycin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Regorafenib belongs to Oncology.
Why it happens
Dexamethasone induces CYP3A4, increasing the metabolism of regorafenib.
What to do
Avoid strong CYP3A4 inducers with regorafenib; dexamethasone is a moderate inducer, so use the shortest effective steroid course and monitor tumor response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Regorafenib
Frequently asked questions
Can I take Dexamethasone-tobramycin with Regorafenib?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone is a CYP3A4 inducer and can lower regorafenib exposure while altering the balance of its active metabolites. This may reduce antitumor efficacy. The effect is mainly relevant with prolonged or high-dose steroid use.
How serious is the interaction between Dexamethasone-tobramycin and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inducers with regorafenib; dexamethasone is a moderate inducer, so use the shortest effective steroid course and monitor tumor response and tolerability.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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