Drug interactions
Dexamethasone-tobramycin + Riociguat
Severity: Minor
Dexamethasone-tobramycin and Riociguat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a weak to moderate CYP3A4 inducer and may lower riociguat exposure, reducing its effect on pulmonary hypertension. This is mainly theoretical, and ophthalmic use gives negligible systemic exposure. Systemic dexamethasone could have a modest effect.
What this interaction means in plain words
Dexamethasone-tobramycin and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Riociguat belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by dexamethasone, increasing riociguat metabolism.
What to do
No adjustment is needed with ophthalmic use. If systemic dexamethasone is used long term, monitor clinical response and blood pressure and titrate riociguat accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Riociguat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Riociguat?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a weak to moderate CYP3A4 inducer and may lower riociguat exposure, reducing its effect on pulmonary hypertension. This is mainly theoretical, and ophthalmic use gives negligible systemic exposure. Systemic dexamethasone could have a modest effect.
How serious is the interaction between Dexamethasone-tobramycin and Riociguat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed with ophthalmic use. If systemic dexamethasone is used long term, monitor clinical response and blood pressure and titrate riociguat accordingly.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
