Drug interactions
Dexamethasone-tobramycin + Roflumilast
Severity: Moderate
Dexamethasone-tobramycin and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and lower roflumilast and its active N-oxide metabolite exposure. Reduced efficacy in COPD is possible. Roflumilast labeling advises against combination with strong CYP inducers, and dexamethasone is a weaker inducer.
What this interaction means in plain words
Dexamethasone-tobramycin and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Roflumilast belongs to Respiratory.
Why it happens
Dexamethasone induces CYP3A4, increasing roflumilast clearance.
What to do
Monitor COPD control for loss of effect when dexamethasone is used long term with roflumilast. Reassess therapy if exacerbations increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Roflumilast, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Roflumilast
Frequently asked questions
Can I take Dexamethasone-tobramycin with Roflumilast?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may induce CYP3A4 and lower roflumilast and its active N-oxide metabolite exposure. Reduced efficacy in COPD is possible. Roflumilast labeling advises against combination with strong CYP inducers, and dexamethasone is a weaker inducer.
How serious is the interaction between Dexamethasone-tobramycin and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor COPD control for loss of effect when dexamethasone is used long term with roflumilast. Reassess therapy if exacerbations increase.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
