Drug interactions
Dexamethasone-tobramycin + Secobarbital
Severity: Moderate
Dexamethasone-tobramycin and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can substantially lower dexamethasone concentrations, weakening its anti-inflammatory or replacement effect. Additive sedation from the barbiturate is unrelated to this interaction but should be remembered.
What this interaction means in plain words
Dexamethasone-tobramycin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Secobarbital belongs to Central Nervous System.
Why it happens
Secobarbital induces CYP3A4, accelerating dexamethasone metabolism.
What to do
Monitor clinical response to dexamethasone and increase the dose if efficacy is lost. Reduce the dose again when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Secobarbital?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can substantially lower dexamethasone concentrations, weakening its anti-inflammatory or replacement effect. Additive sedation from the barbiturate is unrelated to this interaction but should be remembered.
How serious is the interaction between Dexamethasone-tobramycin and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to dexamethasone and increase the dose if efficacy is lost. Reduce the dose again when the barbiturate is stopped.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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