Drug interactions
Dexamethasone-tobramycin + Ticagrelor
Severity: Moderate
Dexamethasone-tobramycin and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may reduce ticagrelor exposure by inducing CYP3A4, potentially lowering antiplatelet effect and raising the risk of stent thrombosis or ischemic events. Corticosteroids also increase gastrointestinal bleeding risk with antiplatelet drugs.
What this interaction means in plain words
Dexamethasone-tobramycin and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Ticagrelor belongs to Cardiovascular.
Why it happens
Dexamethasone induces CYP3A4, increasing ticagrelor clearance.
What to do
Limit the duration of dexamethasone and monitor for ischemic events and GI bleeding. Consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Ticagrelor?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may reduce ticagrelor exposure by inducing CYP3A4, potentially lowering antiplatelet effect and raising the risk of stent thrombosis or ischemic events. Corticosteroids also increase gastrointestinal bleeding risk with antiplatelet drugs.
How serious is the interaction between Dexamethasone-tobramycin and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of dexamethasone and monitor for ischemic events and GI bleeding. Consider gastroprotection.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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