Drug interactions
Dexamethasone-tobramycin + Tolazamide
Severity: Minor
Dexamethasone-tobramycin and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone raises blood glucose and may weaken the glucose-lowering effect of tolazamide. Topical use carries little risk, but systemic steroid exposure can destabilize diabetes control.
What this interaction means in plain words
Dexamethasone-tobramycin and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Tolazamide belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance opposes the insulin secretagogue effect of sulfonylureas.
What to do
Monitor blood glucose during systemic steroid treatment and increase antidiabetic therapy as needed, reducing it again when steroids stop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Dexamethasone-tobramycin with Tolazamide?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone raises blood glucose and may weaken the glucose-lowering effect of tolazamide. Topical use carries little risk, but systemic steroid exposure can destabilize diabetes control.
How serious is the interaction between Dexamethasone-tobramycin and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during systemic steroid treatment and increase antidiabetic therapy as needed, reducing it again when steroids stop.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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