Drug interactions
Dexamethasone-tobramycin + Tolfenamic acid
Severity: Moderate
Dexamethasone-tobramycin and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroid and NSAID use increases the risk of peptic ulceration and gastrointestinal bleeding. The NSAID may also add to the nephrotoxic risk of systemic tobramycin.
What this interaction means in plain words
Dexamethasone-tobramycin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury from prostaglandin inhibition and corticosteroid effects.
What to do
Use the shortest possible duration and consider a proton pump inhibitor. Monitor for GI bleeding symptoms and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Dexamethasone-tobramycin with Tolfenamic acid?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent corticosteroid and NSAID use increases the risk of peptic ulceration and gastrointestinal bleeding. The NSAID may also add to the nephrotoxic risk of systemic tobramycin.
How serious is the interaction between Dexamethasone-tobramycin and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest possible duration and consider a proton pump inhibitor. Monitor for GI bleeding symptoms and renal function.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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