Drug interactions
Dexamethasone-tobramycin + Verapamil
Severity: Moderate
Dexamethasone-tobramycin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and P-gp and can raise dexamethasone exposure, increasing steroid adverse effects. Dexamethasone may in turn lower verapamil levels through CYP3A4 induction, reducing blood pressure or rate control.
What this interaction means in plain words
Dexamethasone-tobramycin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4 and P-gp, while dexamethasone induces CYP3A4, producing bidirectional changes in exposure.
What to do
Monitor blood pressure, heart rate and steroid adverse effects such as hyperglycemia. Adjust the verapamil or dexamethasone dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Verapamil?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits CYP3A4 and P-gp and can raise dexamethasone exposure, increasing steroid adverse effects. Dexamethasone may in turn lower verapamil levels through CYP3A4 induction, reducing blood pressure or rate control.
How serious is the interaction between Dexamethasone-tobramycin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and steroid adverse effects such as hyperglycemia. Adjust the verapamil or dexamethasone dose according to response.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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