Drug interactions
Dexamethasone-tobramycin + Voclosporin
Severity: Moderate
Dexamethasone-tobramycin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause nephrotoxicity, and tobramycin can also injure the kidney when absorbed systemically. Together they may increase the risk of kidney injury. Ophthalmic tobramycin has little systemic exposure, reducing this risk.
What this interaction means in plain words
Dexamethasone-tobramycin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity from calcineurin inhibitor-induced renal vasoconstriction and aminoglycoside tubular toxicity.
What to do
If systemic tobramycin is needed, monitor serum creatinine and eGFR and tobramycin levels closely. Adjust the dose of either drug if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Voclosporin?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor that can cause nephrotoxicity, and tobramycin can also injure the kidney when absorbed systemically. Together they may increase the risk of kidney injury. Ophthalmic tobramycin has little systemic exposure, reducing this risk.
How serious is the interaction between Dexamethasone-tobramycin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If systemic tobramycin is needed, monitor serum creatinine and eGFR and tobramycin levels closely. Adjust the dose of either drug if renal function deteriorates.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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