Drug interactions
Dexfenfluramine + Imatinib
Severity: Minor
Dexfenfluramine and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and could modestly raise dexfenfluramine levels. Dexfenfluramine has been withdrawn from the market because of valvular heart disease and pulmonary hypertension, so the interaction has little practical relevance.
What this interaction means in plain words
Dexfenfluramine and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Imatinib inhibits CYP2D6, a possible metabolic pathway for dexfenfluramine.
What to do
Dexfenfluramine is no longer marketed and should not be used. If encountered, monitor for serotonergic and cardiovascular effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Dexfenfluramine with Imatinib?
MediHelp rates the interaction as minor. Dexfenfluramine and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP2D6 and could modestly raise dexfenfluramine levels. Dexfenfluramine has been withdrawn from the market because of valvular heart disease and pulmonary hypertension, so the interaction has little practical relevance.
How serious is the interaction between Dexfenfluramine and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dexfenfluramine is no longer marketed and should not be used. If encountered, monitor for serotonergic and cardiovascular effects.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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