Drug interactions
Dexfenfluramine + Linezolid
Severity: Contraindicated
Dexfenfluramine and Linezolid: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine releases serotonin and linezolid inhibits MAO. The combination risks serotonin syndrome and hypertensive reactions.
What this interaction means in plain words
Dexfenfluramine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition with serotonin-releasing activity gives additive serotonergic effects.
What to do
Avoid concurrent use. Select another antibiotic and monitor for serotonin toxicity and hypertension if exposure occurred.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexfenfluramine and Linezolid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Linezolid?
MediHelp rates the interaction as contraindicated. Dexfenfluramine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dexfenfluramine releases serotonin and linezolid inhibits MAO. The combination risks serotonin syndrome and hypertensive reactions.
How serious is the interaction between Dexfenfluramine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Select another antibiotic and monitor for serotonin toxicity and hypertension if exposure occurred.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
