Drug interactions
Dexfenfluramine + Maprotiline
Severity: Major
Dexfenfluramine and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine releases serotonin, and combining it with maprotiline may produce serotonin toxicity and unpredictable changes in blood pressure. Dexfenfluramine has been withdrawn from most markets.
What this interaction means in plain words
Dexfenfluramine and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic and noradrenergic effects.
What to do
Avoid the combination. If it was used, monitor for serotonin syndrome and blood pressure changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Maprotiline?
MediHelp rates the interaction as major. Dexfenfluramine and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dexfenfluramine releases serotonin, and combining it with maprotiline may produce serotonin toxicity and unpredictable changes in blood pressure. Dexfenfluramine has been withdrawn from most markets.
How serious is the interaction between Dexfenfluramine and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it was used, monitor for serotonin syndrome and blood pressure changes.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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