Drug interactions
Dexfenfluramine + Metaxalone
Severity: Moderate
Dexfenfluramine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is a serotonergic anorectic, now withdrawn in most markets, and its interaction with metaxalone on sedation is unclear. Metaxalone has also been associated with serotonin toxicity when combined with serotonergic drugs.
What this interaction means in plain words
Dexfenfluramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Unclear net effect on sedation, with a theoretical additive serotonergic contribution.
What to do
Monitor for agitation, tremor, sweating or fever suggesting serotonin toxicity. Reassess the need for both drugs if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Dexfenfluramine with Metaxalone?
MediHelp rates the interaction as moderate. Dexfenfluramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine is a serotonergic anorectic, now withdrawn in most markets, and its interaction with metaxalone on sedation is unclear. Metaxalone has also been associated with serotonin toxicity when combined with serotonergic drugs.
How serious is the interaction between Dexfenfluramine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, sweating or fever suggesting serotonin toxicity. Reassess the need for both drugs if symptoms occur.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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