Drug interactions
Dexfenfluramine + Propafenone
Severity: Minor
Dexfenfluramine and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone strongly inhibits CYP2D6, which may raise exposure to CYP2D6 substrates such as dexfenfluramine. Dexfenfluramine has been withdrawn from the market, and clinical significance of this interaction is uncertain.
What this interaction means in plain words
Dexfenfluramine and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Propafenone inhibition of CYP2D6-mediated metabolism.
What to do
Dexfenfluramine is no longer marketed, so no routine action is required. If encountered, monitor for serotonergic and cardiovascular adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Propafenone?
MediHelp rates the interaction as minor. Dexfenfluramine and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propafenone strongly inhibits CYP2D6, which may raise exposure to CYP2D6 substrates such as dexfenfluramine. Dexfenfluramine has been withdrawn from the market, and clinical significance of this interaction is uncertain.
How serious is the interaction between Dexfenfluramine and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dexfenfluramine is no longer marketed, so no routine action is required. If encountered, monitor for serotonergic and cardiovascular adverse effects.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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