Drug interactions
Dexfenfluramine + Quinidine
Severity: Moderate
Dexfenfluramine and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is partly metabolized by CYP2D6, so quinidine may raise its concentrations. Dexfenfluramine has been withdrawn from the market in most regions, and the clinical impact of this interaction is poorly documented.
What this interaction means in plain words
Dexfenfluramine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinidine inhibits CYP2D6-mediated metabolism of dexfenfluramine.
What to do
If the combination is unavoidable, monitor for increased serotonergic and cardiovascular adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Quinidine?
MediHelp rates the interaction as moderate. Dexfenfluramine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine is partly metabolized by CYP2D6, so quinidine may raise its concentrations. Dexfenfluramine has been withdrawn from the market in most regions, and the clinical impact of this interaction is poorly documented.
How serious is the interaction between Dexfenfluramine and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is unavoidable, monitor for increased serotonergic and cardiovascular adverse effects.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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