Drug interactions
Dexfenfluramine + Sumatriptan
Severity: Major
Dexfenfluramine and Sumatriptan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine releases serotonin and blocks its reuptake, and combining it with a triptan could increase the risk of serotonin syndrome. The drug has been withdrawn from most markets, so the combination is rarely encountered.
What this interaction means in plain words
Dexfenfluramine and Sumatriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects from serotonin release and reuptake inhibition with 5-HT1 receptor agonism.
What to do
Avoid the combination. If serotonin syndrome features such as agitation, hyperreflexia, tremor or hyperthermia occur, stop both agents and give supportive care.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Sumatriptan?
MediHelp rates the interaction as major. Dexfenfluramine and Sumatriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dexfenfluramine releases serotonin and blocks its reuptake, and combining it with a triptan could increase the risk of serotonin syndrome. The drug has been withdrawn from most markets, so the combination is rarely encountered.
How serious is the interaction between Dexfenfluramine and Sumatriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If serotonin syndrome features such as agitation, hyperreflexia, tremor or hyperthermia occur, stop both agents and give supportive care.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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