Drug reference
sumatriptan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Migraine Drugs)
Mechanism of action
Selective 5-HT1B and 5-HT1D receptor agonist in cranial arteries; elicits vasoconstrictive and anti-inflammatory effects; associated with antidromic neuronal transmission and relief of migraine headache
Common side effects
- Injection site reaction
- Dizziness
- Diaphoresis
- Paresthesia
- Warm/hot sensation
- Chest discomfort
- Jaw or neck tightness
Known interactions (8)
- almotriptan + sumatriptan Contraindicated
- eletriptan + sumatriptan Contraindicated
- ergotamine + sumatriptan Contraindicated
- frovatriptan + sumatriptan Contraindicated
- isocarboxazid + sumatriptan Contraindicated
- phenelzine + sumatriptan Contraindicated
- bromocriptine + sumatriptan Moderate
- cabergoline + sumatriptan Moderate
Related conditions
Frequently asked questions
What drug class is sumatriptan?
sumatriptan belongs to: Central Nervous System.
How does sumatriptan work?
Selective 5-HT1B and 5-HT1D receptor agonist in cranial arteries; elicits vasoconstrictive and anti-inflammatory effects; associated with antidromic neuronal transmission and relief of migraine headache
What are the common side effects of sumatriptan?
Injection site reaction, Dizziness, Diaphoresis, Paresthesia, Warm/hot sensation, Chest discomfort, Jaw or neck tightness
Which drugs interact with sumatriptan?
almotriptan, eletriptan, ergotamine, frovatriptan, isocarboxazid, phenelzine, bromocriptine, cabergoline
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