Drug interactions
Dexlansoprazole + Dextroamphetamine
Severity: Minor
Dexlansoprazole and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
PPIs can speed absorption of amphetamine salts with extended-release formulations, shifting the peak earlier, while total exposure stays similar. Clinically this is unlikely to matter.
What this interaction means in plain words
Dexlansoprazole and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Higher gastric pH alters release from pH-dependent extended-release formulations, shortening time to peak.
What to do
No dose change is needed; be aware of possible earlier onset or stronger early effects with extended-release products.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Dextroamphetamine?
MediHelp rates the interaction as minor. Dexlansoprazole and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. PPIs can speed absorption of amphetamine salts with extended-release formulations, shifting the peak earlier, while total exposure stays similar. Clinically this is unlikely to matter.
How serious is the interaction between Dexlansoprazole and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; be aware of possible earlier onset or stronger early effects with extended-release products.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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