Drug interactions
Dexlansoprazole + Diazepam intranasal
Severity: Moderate
Dexlansoprazole and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexlansoprazole may weakly inhibit CYP2C19, which helps clear diazepam and its active metabolite. This may prolong or intensify sedation.
What this interaction means in plain words
Dexlansoprazole and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2C19 inhibition by dexlansoprazole reduces diazepam clearance.
What to do
Monitor for excess sedation and respiratory depression, especially in elderly patients or with repeated dosing. Consider lower or less frequent diazepam doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Diazepam intranasal?
MediHelp rates the interaction as moderate. Dexlansoprazole and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexlansoprazole may weakly inhibit CYP2C19, which helps clear diazepam and its active metabolite. This may prolong or intensify sedation.
How serious is the interaction between Dexlansoprazole and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression, especially in elderly patients or with repeated dosing. Consider lower or less frequent diazepam doses.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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