Drug interactions
Dexlansoprazole + Dichlorphenamide
Severity: Moderate
Dexlansoprazole and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, so combined use may increase the risk of hypokalemia. This matters in patients with periodic paralysis who already have potassium disturbances.
What this interaction means in plain words
Dexlansoprazole and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive potassium loss: dichlorphenamide causes renal potassium wasting, and PPIs can contribute to hypokalemia.
What to do
Monitor serum potassium and magnesium at baseline and periodically, and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dexlansoprazole with Dichlorphenamide?
MediHelp rates the interaction as moderate. Dexlansoprazole and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, so combined use may increase the risk of hypokalemia. This matters in patients with periodic paralysis who already have potassium disturbances.
How serious is the interaction between Dexlansoprazole and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium at baseline and periodically, and replace as needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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