Drug interactions
Dexlansoprazole + Ferrous sulfate
Severity: Moderate
Dexlansoprazole and Ferrous sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic acid suppression reduces absorption of non-heme oral iron salts, which may impair correction of iron deficiency. The effect is more relevant with prolonged use.
What this interaction means in plain words
Dexlansoprazole and Ferrous sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Ferrous sulfate belongs to Miscellaneous.
Why it happens
Elevated gastric pH reduces solubilization of ferric iron into absorbable ferrous form.
What to do
Monitor ferritin and hemoglobin, and consider vitamin C, a dosage increase, or intravenous iron if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Ferrous sulfate
Frequently asked questions
Can I take Dexlansoprazole with Ferrous sulfate?
MediHelp rates the interaction as moderate. Dexlansoprazole and Ferrous sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chronic acid suppression reduces absorption of non-heme oral iron salts, which may impair correction of iron deficiency. The effect is more relevant with prolonged use.
How serious is the interaction between Dexlansoprazole and Ferrous sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ferritin and hemoglobin, and consider vitamin C, a dosage increase, or intravenous iron if response is inadequate.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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