Drug interactions
Dexlansoprazole + Fosphenytoin
Severity: Moderate
Dexlansoprazole and Fosphenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin (from fosphenytoin) induces CYP enzymes and may lower dexlansoprazole exposure. Conversely, PPIs can slightly raise phenytoin levels. Acid control or phenytoin levels may change.
What this interaction means in plain words
Dexlansoprazole and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4 and CYP2C19, speeding PPI clearance, while PPIs may inhibit CYP2C19-mediated phenytoin metabolism.
What to do
Monitor for loss of acid control and check phenytoin levels when starting or stopping the PPI. Adjust the dose of either drug as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Fosphenytoin?
MediHelp rates the interaction as moderate. Dexlansoprazole and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin (from fosphenytoin) induces CYP enzymes and may lower dexlansoprazole exposure. Conversely, PPIs can slightly raise phenytoin levels. Acid control or phenytoin levels may change.
How serious is the interaction between Dexlansoprazole and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of acid control and check phenytoin levels when starting or stopping the PPI. Adjust the dose of either drug as needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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