Drug interactions
Dexlansoprazole + Indinavir
Severity: Moderate
Dexlansoprazole and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir needs an acidic stomach for optimal absorption. Acid suppression by dexlansoprazole can lower indinavir exposure, risking reduced antiviral efficacy and resistance.
What this interaction means in plain words
Dexlansoprazole and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised gastric pH reduces indinavir dissolution and absorption.
What to do
Avoid the combination where possible, or use an alternative antiretroviral. If it is unavoidable, monitor HIV viral load closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Indinavir?
MediHelp rates the interaction as moderate. Dexlansoprazole and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir needs an acidic stomach for optimal absorption. Acid suppression by dexlansoprazole can lower indinavir exposure, risking reduced antiviral efficacy and resistance.
How serious is the interaction between Dexlansoprazole and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use an alternative antiretroviral. If it is unavoidable, monitor HIV viral load closely.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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