Drug interactions
Dexlansoprazole + Infigratinib
Severity: Major
Dexlansoprazole and Infigratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib has pH-dependent solubility, so reduced gastric acidity lowers its absorption. Dexlansoprazole may decrease infigratinib exposure and weaken its anticancer effect.
What this interaction means in plain words
Dexlansoprazole and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Increased gastric pH reduces infigratinib solubility and absorption.
What to do
Avoid PPIs with infigratinib. If acid reduction is required, use a locally acting antacid separated from infigratinib by the interval stated in the labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Infigratinib?
MediHelp rates the interaction as major. Dexlansoprazole and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Infigratinib has pH-dependent solubility, so reduced gastric acidity lowers its absorption. Dexlansoprazole may decrease infigratinib exposure and weaken its anticancer effect.
How serious is the interaction between Dexlansoprazole and Infigratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with infigratinib. If acid reduction is required, use a locally acting antacid separated from infigratinib by the interval stated in the labeling.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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