Drug interactions
Dexlansoprazole + Ledipasvir / sofosbuvir
Severity: Moderate
Dexlansoprazole and Ledipasvir / sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir is less soluble at higher pH, so acid suppression can lower its absorption and risk reducing the cure rate of hepatitis C therapy.
What this interaction means in plain words
Dexlansoprazole and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased gastric pH reduces ledipasvir solubility and absorption.
What to do
Give the PPI simultaneously with ledipasvir/sofosbuvir under fasting conditions, at a dose no higher than omeprazole 20 mg equivalents. Avoid higher PPI doses where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Ledipasvir / sofosbuvir?
MediHelp rates the interaction as moderate. Dexlansoprazole and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir is less soluble at higher pH, so acid suppression can lower its absorption and risk reducing the cure rate of hepatitis C therapy.
How serious is the interaction between Dexlansoprazole and Ledipasvir / sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the PPI simultaneously with ledipasvir/sofosbuvir under fasting conditions, at a dose no higher than omeprazole 20 mg equivalents. Avoid higher PPI doses where possible.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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