Drug interactions
Dexlansoprazole + Liotrix
Severity: Moderate
Dexlansoprazole and Liotrix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexlansoprazole may reduce absorption of the levothyroxine component of liotrix by raising gastric pH. Reports are conflicting, but some patients need higher thyroid hormone doses.
What this interaction means in plain words
Dexlansoprazole and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced gastric acidity may impair dissolution and absorption of oral thyroid hormone.
What to do
Monitor TSH and free T4 six to eight weeks after starting or stopping dexlansoprazole and adjust the liotrix dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Liotrix?
MediHelp rates the interaction as moderate. Dexlansoprazole and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexlansoprazole may reduce absorption of the levothyroxine component of liotrix by raising gastric pH. Reports are conflicting, but some patients need higher thyroid hormone doses.
How serious is the interaction between Dexlansoprazole and Liotrix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor TSH and free T4 six to eight weeks after starting or stopping dexlansoprazole and adjust the liotrix dose as needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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