Drug interactions
Dexlansoprazole + Lumacaftor / ivacaftor
Severity: Minor
Dexlansoprazole and Lumacaftor / ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor induces CYP enzymes, which may reduce dexlansoprazole exposure and acid suppression. Ivacaftor may inhibit CYP2C19, so the net effect is uncertain.
What this interaction means in plain words
Dexlansoprazole and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lumacaftor induces CYP3A4 and CYP2C19, which increases dexlansoprazole clearance, partly offset by ivacaftor inhibition.
What to do
Monitor for reduced acid control and increase the PPI dose if symptoms persist. No empirical adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Lumacaftor / ivacaftor?
MediHelp rates the interaction as minor. Dexlansoprazole and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor induces CYP enzymes, which may reduce dexlansoprazole exposure and acid suppression. Ivacaftor may inhibit CYP2C19, so the net effect is uncertain.
How serious is the interaction between Dexlansoprazole and Lumacaftor / ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced acid control and increase the PPI dose if symptoms persist. No empirical adjustment is needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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