Drug interactions
Dexlansoprazole + Mycophenolate
Severity: Moderate
Dexlansoprazole and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Raising gastric pH with a proton pump inhibitor can lower absorption of mycophenolic acid from mycophenolate mofetil. This may reduce immunosuppressive exposure, although the clinical importance is uncertain and the enteric-coated sodium salt is less affected.
What this interaction means in plain words
Dexlansoprazole and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Higher gastric pH reduces dissolution and absorption of mycophenolate mofetil, lowering mycophenolic acid exposure.
What to do
Monitor for signs of rejection or reduced immunosuppression, and consider mycophenolic acid level monitoring; consider enteric-coated mycophenolate sodium or the lowest effective PPI dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Mycophenolate?
MediHelp rates the interaction as moderate. Dexlansoprazole and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Raising gastric pH with a proton pump inhibitor can lower absorption of mycophenolic acid from mycophenolate mofetil. This may reduce immunosuppressive exposure, although the clinical importance is uncertain and the enteric-coated sodium salt is less affected.
How serious is the interaction between Dexlansoprazole and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of rejection or reduced immunosuppression, and consider mycophenolic acid level monitoring; consider enteric-coated mycophenolate sodium or the lowest effective PPI dose.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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