Drug interactions
Dexlansoprazole + Phenobarbital
Severity: Moderate
Dexlansoprazole and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP enzymes, including CYP3A4 and CYP2C19, which metabolize dexlansoprazole. Dexlansoprazole exposure may fall and acid suppression may weaken.
What this interaction means in plain words
Dexlansoprazole and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction by phenobarbital increases dexlansoprazole metabolism.
What to do
Monitor for symptom control and consider a higher PPI dose or alternative acid suppression if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Phenobarbital?
MediHelp rates the interaction as moderate. Dexlansoprazole and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces CYP enzymes, including CYP3A4 and CYP2C19, which metabolize dexlansoprazole. Dexlansoprazole exposure may fall and acid suppression may weaken.
How serious is the interaction between Dexlansoprazole and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptom control and consider a higher PPI dose or alternative acid suppression if response is inadequate.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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