Drug interactions
Dexlansoprazole + Phenytoin
Severity: Moderate
Dexlansoprazole and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP enzymes and may lower dexlansoprazole exposure, reducing acid suppression. Dexlansoprazole may also alter phenytoin levels, although this is not well documented.
What this interaction means in plain words
Dexlansoprazole and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4 and CYP2C19, increasing dexlansoprazole clearance.
What to do
Monitor for breakthrough reflux symptoms and adjust the PPI dose; check phenytoin levels if toxicity or loss of seizure control occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Phenytoin?
MediHelp rates the interaction as moderate. Dexlansoprazole and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces CYP enzymes and may lower dexlansoprazole exposure, reducing acid suppression. Dexlansoprazole may also alter phenytoin levels, although this is not well documented.
How serious is the interaction between Dexlansoprazole and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough reflux symptoms and adjust the PPI dose; check phenytoin levels if toxicity or loss of seizure control occurs.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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