Drug interactions
Dexlansoprazole + Rifampin
Severity: Moderate
Dexlansoprazole and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces the enzymes that metabolize dexlansoprazole, which can substantially lower PPI concentrations. Acid suppression may become inadequate.
What this interaction means in plain words
Dexlansoprazole and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP2C19 and CYP3A4, increasing dexlansoprazole clearance.
What to do
Monitor for loss of symptom control and increase the PPI dose or use an alternative acid-suppressing agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Rifampin?
MediHelp rates the interaction as moderate. Dexlansoprazole and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin strongly induces the enzymes that metabolize dexlansoprazole, which can substantially lower PPI concentrations. Acid suppression may become inadequate.
How serious is the interaction between Dexlansoprazole and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and increase the PPI dose or use an alternative acid-suppressing agent if needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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