Drug interactions
Dexlansoprazole + Saquinavir
Severity: Major
Dexlansoprazole and Saquinavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole has been shown to raise saquinavir exposure, and other PPIs may act similarly. Higher saquinavir levels increase the risk of adverse effects including QT and PR interval prolongation.
What this interaction means in plain words
Dexlansoprazole and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Probably increased saquinavir absorption through the pH effect or altered metabolism or transport; the mechanism is not clearly established.
What to do
Monitor ECG and for saquinavir toxicity when combined; follow saquinavir labeling on PPI use and avoid if QT risk factors exist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Saquinavir?
MediHelp rates the interaction as major. Dexlansoprazole and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omeprazole has been shown to raise saquinavir exposure, and other PPIs may act similarly. Higher saquinavir levels increase the risk of adverse effects including QT and PR interval prolongation.
How serious is the interaction between Dexlansoprazole and Saquinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for saquinavir toxicity when combined; follow saquinavir labeling on PPI use and avoid if QT risk factors exist.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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