Drug interactions
Dexlansoprazole + Secretin
Severity: Moderate
Dexlansoprazole and Secretin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
PPIs raise serum gastrin and can cause a false-positive secretin stimulation test for gastrinoma. This may lead to misdiagnosis and unnecessary investigation.
What this interaction means in plain words
Dexlansoprazole and Secretin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Acid suppression causes hypergastrinemia, producing an exaggerated gastrin response to secretin.
What to do
Where clinically feasible, temporarily stop dexlansoprazole before testing, with specialist supervision and an acid-control plan, and interpret results with the PPI history in mind.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Secretin?
MediHelp rates the interaction as moderate. Dexlansoprazole and Secretin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. PPIs raise serum gastrin and can cause a false-positive secretin stimulation test for gastrinoma. This may lead to misdiagnosis and unnecessary investigation.
How serious is the interaction between Dexlansoprazole and Secretin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where clinically feasible, temporarily stop dexlansoprazole before testing, with specialist supervision and an acid-control plan, and interpret results with the PPI history in mind.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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