Drug interactions
Dexlansoprazole + Sofosbuvir / velpatasvir
Severity: Major
Dexlansoprazole and Sofosbuvir / velpatasvir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir solubility drops sharply at higher gastric pH. PPIs can reduce velpatasvir exposure and risk reduced hepatitis C cure rates.
What this interaction means in plain words
Dexlansoprazole and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Raised gastric pH reduces velpatasvir dissolution and absorption.
What to do
Avoid the combination. If it is medically necessary, follow the labeling for a PPI given after sofosbuvir/velpatasvir with food, at the lowest dose, with close monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as major. Dexlansoprazole and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Velpatasvir solubility drops sharply at higher gastric pH. PPIs can reduce velpatasvir exposure and risk reduced hepatitis C cure rates.
How serious is the interaction between Dexlansoprazole and Sofosbuvir / velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it is medically necessary, follow the labeling for a PPI given after sofosbuvir/velpatasvir with food, at the lowest dose, with close monitoring.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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