Drug interactions
Dexlansoprazole + Thyroid desiccated
Severity: Minor
Dexlansoprazole and Thyroid desiccated: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gastric acid aids absorption of oral thyroid hormone, so long-term PPI use may reduce absorption and raise levothyroxine-type requirements in some patients. Evidence is mixed and the effect is usually small, but it can show up as a rise in TSH.
What this interaction means in plain words
Dexlansoprazole and Thyroid desiccated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Higher gastric pH may impair dissolution and absorption of oral thyroid hormones.
What to do
Check TSH about 6 to 8 weeks after starting or stopping the PPI and adjust the thyroid dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Thyroid desiccated?
MediHelp rates the interaction as minor. Dexlansoprazole and Thyroid desiccated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gastric acid aids absorption of oral thyroid hormone, so long-term PPI use may reduce absorption and raise levothyroxine-type requirements in some patients. Evidence is mixed and the effect is usually small, but it can show up as a rise in TSH.
How serious is the interaction between Dexlansoprazole and Thyroid desiccated?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH about 6 to 8 weeks after starting or stopping the PPI and adjust the thyroid dose if needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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