Drug interactions
Dexmedetomidine + Dextromoramide
Severity: Major
Dexmedetomidine and Dextromoramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid, and with dexmedetomidine it can cause marked sedation, respiratory depression, bradycardia and hypotension.
What this interaction means in plain words
Dexmedetomidine and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid receptor and alpha-2 adrenergic agonism.
What to do
Use reduced doses with continuous monitoring of respiration, oxygen saturation and hemodynamics, with resuscitation equipment available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexmedetomidine and Dextromoramide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Dextromoramide?
MediHelp rates the interaction as major. Dexmedetomidine and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid, and with dexmedetomidine it can cause marked sedation, respiratory depression, bradycardia and hypotension.
How serious is the interaction between Dexmedetomidine and Dextromoramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses with continuous monitoring of respiration, oxygen saturation and hemodynamics, with resuscitation equipment available.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Diamorphine. The full list is on the Dexmedetomidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
